周琪 研究员，中国科学院动物研究所，生殖生物学国家重点实验室生殖工程组。从事哺乳动物克隆、体细胞重编程机制及干细胞等方面的研究。现任中国科学院动物研究所所长助理，生殖生物学国家重点实验室副主任，科技部政策专家顾问组成员，中国科学院动物研究所学术委员会副主任，中国动物学会生殖生物学分会理事，中国干细胞学会理事；国际干细胞组织（ISCF）中国代表，国际转基因技术协会（ISTT）终身荣誉会员。
　　生于1970年4月，1996年毕业于东北农业大学，获理学博士学位；1997年进入中国科学院发育生物学研究所博士后流动站；1999年在中国科学院发育生物学研究所获副研究员任职资格；1999年至2002年，在法国国立农业研究中心做博士后及项目负责人；2001年入选中国科学院“百人计划”。
　　自1990年从事细胞核移植研究以来，主要从事细胞核移植、干细胞全能性与定向分化机理研究；利用体细胞成功克隆小鼠，证明了小鼠克隆的可重复性；世界上首次克隆成功大鼠及雪貂；已经建立兔、小鼠、牛、山羊和大鼠等物种克隆动物模型，利用小鼠构建了人类第三代辅助生殖技术--胚胎种植前诊断（PGD）的动物模型，开展了辅助生殖技术安全性评估工作；建立了治疗性克隆来源的鼠胚胎干细胞系、人类及非人灵长类胚胎干细胞系，及小鼠、人、非人灵长类iPS细胞系；改进发明了4项体细胞核移植技术，获得了克隆技术发明专利一项；利用iPS细胞通过四倍体补偿实验获得成活健康小鼠，首次证明了iPS细胞的全能性；随后发现并明确证明了决定小鼠干细胞多能性的关键基因决定簇，首次发现了判断干细胞干细胞多能性水平的分子标识。
　　在进行基础研究的同时，周琪研究员致力于推动基础研究向临床应用的转化；在国内积极推动建设合作研究网络，成功地组织起包括灵长类动物基地、基因组学平台、蛋白质组学平台、临床试验基地等10余家单位在内的科研网络；在国际上积极组织和参加重大项目，目前已经参加2项欧盟第六框架计划项目，并建议和推动中国科学院与与法国农科院（INRA）建立了中法胚胎干细胞生物学联合实验室，正式协议已于2005年11月4日签署。
　　回国以来先后获得中国科学院百人计划、国家杰出青年基金的支持；承担了国家高技术研究发展计划(863计划)项目、国家重点基础发展计划（973）、欧盟第六框架研究计划项目、科技部国际合作重点项目、国家自然科学基金委员会国际合作重大项目、面上项目、中法先进研究计划（PRA）等项目。
周琪研究员目前已发表SCI收录论文45篇，分别发表在Science、Nature、Stem Cells、Journal of Biological Chemistry、Cell Research、Human Reproduction 、Development 、Cloning & Stem cells和Biology of Reproduction等刊物，在国际动物克隆和干细胞研究领域得到了同行的认同和承认，评价文章多次发表在 Nature, Science, Nature Review Genetics 等刊物。
　　成功克隆小鼠的工作在2000年被Ian Wilmut 博士（创造Dolly羊的科学家）评价为“该领域迄今为止最重要的文章之一”；所领导的实验室是目前国际上为数不多的可以从事小鼠核移植研究工作的实验室（Nature Biotechnology, 22(12),1506-08, 2004）；体细胞克隆大鼠，被Nature、Science和Nature Review Genetic上的相关评论认为“这项研究的成功为人类疾病的动物模型研究领域带来了巨大的进步，将会大大加速基因敲除大鼠研究的进展”（Nature Review Genetics, 2003）；四倍体补偿iPS克隆小鼠的获得，得到了Nature、Science、Reuters等数家杂志及媒体的评论，当选为2009年度中国基础研究十大新闻及两院院士评选的2009年中国十大科技进展新闻，并入选了2009年美国《时代周刊》评选的年度十大医学突破。

1. Zhao XY, Li W, Lv Z, Zeng F and Zhou Q*. (2010) Production of mice using iPS cells and tetraploid complementation. Nat Protoc. 5(5):963-71
2. Liu L, Luo GZ, Yang W, Zhao X, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ, Zhou Q. (2010) Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J Biol Chem. 2010 Apr 13. [Epub ahead of print]
3. Zhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, Hao J, Guo CL, Wang X, Wang L, Zeng F, Zhou Q*. (2010) Efficient and rapid generation of induced pluripotent stem cells using alternative culture medium. Cell Research 20(3):383-386.
4. Yang W, Zhou Q, Wang XJ. (2010) Regulation beyond genome sequences: DNA and histone methylation in ES cells. Front. Biol. 5(1): 41–47
5. Li W, Zhou Q*. (2010) Epigenetic reprogramming: roads to pluripotency. Frontiers in Biology. 5(1): 8–11
6. Lu ZY, Zhu WW, Yu Y, Jin D, Guan YQ, Yao RQ, Zhang Y, Zhang YS, Zhou Q*.(2010) Derivation and long-term culture of human parthenogenetic embryonic stem cells using human foreskin feeders. J Assist Reprod Genet. DOI 10.1007/s10815-010-9408-5
7. Ma M, Zhou L, Guo X, Lv Z, Yu Y, Ding C, Zhang P, Bi Y, Xie J, Wang L, Lin M, Zhou Z, Huo R, Sha J, Zhou Q*. (2009) Decreased cofilin1 expression is important for compaction during early mouse embryo development. Biochim Biophys Acta. 1793(12):1804-1810.
8. Zhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng FY, Zhou Q*. (2009) iPS cells produce viable mice through tetraploid complementation. Nature 461(7260):86-90.
Chen X, Li T, Li X, Xie Y, Guo X, Ji S, Niu Y, Yu Y, Ding C, Yao R, Yang S, Ji W, Zhou Q*. (2009) Neural progenitors derived from monkey embryonic stem cells in a simple monoculture system. Reprod Biomed Online 19(3):426-433.
9. Hao J, Zhu W, Sheng C, Yu Y, Zhou Q*. (2009) Human parthenogenetic embryonic stem cells: one potential resource for cell therapy. Sci China C Life Sci. 52(7):599-602.
10. Dai X, Hao J, Zhou Q*. (2009) A modified culture method significantly improves the development of mouse somatic cell nuclear transfer embryos. Reproduction 138(2):301-308.
11. Yu Y, Wu JD, Fan Y, Lv Z, Guo XJ, Zhao C, Zhou R, Zhang Z, Wang FQ, Xiao M, Chen L, Zhu H, Chen W, Lin M, Liu JY, Zhou ZM, Wang L, Huo H, Zhou Q*, Sha JH. (2009) Evaluation of blastomere biopsy using mouse model indicates the potential high-risk of neurodegenerative disorders in the offspring. Mol Cell Proteomics 8(7):1490-1500.
12. Jin LF, Ji SH, Tang XH, Guo XJ, Lu YQ, Chen HW, Deng HK, Zhou Q*, Ji WZ. (2009) Isolation and characterization of liver epithelial progenitor cells from normal adult rhesus monkeys (Macaca mulatta). Cell Research 19:268-270.
13. Yang S, He X, Niu Y, Hildebrandt TB, Jewgenow K, Goeritz F, Tang X, Chang Y, Zhou Q, Ji WZ*. (2009) Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys. Theriogenology 72(2):243-250.
14. Maalouf WE, Liu Z, Brochard V, Renard JP, Debey P, Beaujean N, Zink D. (2009) Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term. BMC Developmental Biology? 9:11
15. Yu Y, Mai Q, Chen X, Wang L, Gao L, Zhou C, Zhou Q*. (2009) Assessment of the developmental competence of human somatic cell nuclear transfer embryos by oocyte morphology classification. Hum Reprod. 24(3):649-657.
16. Niu Y, Yang S, Yu Y, Ding C, Yang J, Wang S, Ji S, He X, Xie Y, Tang X, Zhou Q*, Ji W*. (2008) Impairments in embryonic genome activation in rhesus monkey somatic cell nuclear transfer embryos. Cloning Stem Cells 10(1):25-36.
17. Ma M, Guo X, Wang F, Zhao C, Liu Z, Shi Z, Wang Y, Zhang P, Zhang K, Wang N, Lin M, Zhou Z, Liu J, Li Q, Wang L, Huo R, Sha J, Zhou Q*. (2008) Protein expression profile of the mouse metaphase-II oocyte. J Proteome Res. 7(11):4821-4830.
18. Wang S, Shen Y, Yuan X, Chen K, Guo X, Chen Y, Niu Y, Li J, Xu RH, Yan X, Zhou Q*, Ji W*. (2008) Dissecting Signaling Pathways That Govern Self-renewal of Rabbit Embryonic Stem Cells. J Biol Chem. 283(51):35929-35940.
19. Fan Y, Tong M, Zhao C, Ding C, Hao J, Lv Z, Dai X, Hai T, Li X, Yao R, Yu Y, Li Z, Wang L, Alice J, Zhou, Q*. (2008) Comparative pluripotency analysis of mouse embryonic stem cells derived from wild-type and infertile hermaphrodite somatic cell nuclear transfer blastocysts. Chinese Science Bulletin 53 (23): 3648-3655.
20. Yang S, Shen Y, Niu Y, Hildebrandt TB, Jewgenow K, Goeritz F, He X, Zhou Q*, Ji W*. (2008) Effects of rhFSH regimen and time interval on ovarian responses to repeated stimulation cycles in rhesus monkeys during a physiologic breeding season. Theriogenology 70(1):108-114.
21. Mai Q, Yu Y, Li T, Wang L, Chen MJ, Huang SZ, Zhou C, Zhou Q*. (2007) Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. Cell Research 17 (12):1008-1019.
22. Yu Y, Ding C, Wang E, Chen X, Li X, Zhao C, Fan Y, Wang L, Beaujean N, Zhou Q, Jouneau A, Ji W. (2007) Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis. Reproduction 133(5):947-954.
23. Mitalipov SM, Zhou Q, Byrne JA, Ji WZ, Norgren RB, Wolf DP. (2007) Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling. Hum Reprod. 22(8):2232-2242.
24. Yang S, He X, Hildebrandt TB, Zhou Q*, Ji WZ*. (2007) Superovulatory response to a low dose single-daily treatment of rhFSH dissolved in polyvinylpyrrolidone in rhesus monkeys. Am J Primatol. 69(11):1278-1284.
25. Yang S, He X, Hildebrandt TB, Jewgenow K, Goeritz F, Tang X, Zhou Q*, Ji WZ*. (2007) Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys. Theriogenology 67(6):1194-1201.
26. Wang S, Tang X, Niu Y, Chen H, Li B, Li T, Zhang X, Hu Z, Zhou Q*, Ji WZ. (2007) Generation and characterization of rabbit embryonic stem cells. Stem Cells 25(2):481-489.
27. Yang J, Yang S, Beaujean N, Niu Y, He X, Xie Y, Tang X, Wang L, Zhou Q*, Ji WZ*. (2007) Epigenetic marks in cloned rhesus monkey embryos: comparison with counterparts produced in vitro. Biol Reprod. 76(1):36-42.
28. Zhao C, Yao R, Hao J, Ding C, Fan Y, Dai X, Li W, Hai T, Liu Z, Yu Y, Wang Y, Hou X, Ji W, Zhou Q, Jouneau A, Zeng F, Wang L. (2007) Establishment of customized mouse stem cell lines by sequential nuclear transfer. Cell Research 17(1):80-87.
29. Yang SH, Ding CH, He XC, Xie YH, Hildebrandt B, Mitalipov M, Tang XH, Wolf DP, Zhou Q*, Ji WZ. (2006) A comparative approach to somatic cell nuclear transfer in the rhesus monkey. Hum Reprod. 21(10):2564-2571.
30. Li Z, Sun X, Chen J, Liu X, Wisely SM, Zhou Q, Renard JP, Leno GH, Engelhardt JF. (2006) Cloned ferrets produced by somatic cell nuclear transfer. Dev Biol. 293(2):439-448.
31. Jouneau A, Zhou Q, Camus A, Brochard V, Maulny L, Collignon J, Renard JP. (2006) Developmental abnormalities of NT mouse embryos appear early after implantation. Development 133(8):1597-1607.
32. Li Z, Chen X, Sun X, Zhou Q, Chen J, Leno GH, Engelhardt JF. (2005) Nuclear transfer of M-phase ferret fibroblasts synchronized with the microtubule inhibitor demecolcine. J Exp Zoolog A Comp Exp Biol. 303(12):1126-1134.
33. Li TQ, Wang SF, Xie YH, Lu YQ, Zhang XZ, Wang L, Yang SH, Wolf D, Zhou Q*, Ji WZ*. (2005) Transplantable neural progenitor populations derived from rhesus monkey embryonic stem cells. Stem Cells 23(9):1295-1303.
34. Li TQ, Wang SF, Xie YH, Lu YQ, Zhang XZ, Wang L, Yang SH, Wolf D, Zhou Q*, Ji WZ*. (2005) Homologous feeder cells support undifferentiated growth and pluripotency in monkey embryonic stem cells. Stem Cells 23(8):1192-1199.
35. Zhou Q, Renard JP, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J. (2003) Generation of fertile cloned rats by regulating oocyte activation. Science 302(5648):1179.
36. Li XM, Li ZY, Jouneau A, Zhou Q*, Renard JP. (2003) Nuclear Transfer: New Advances and Quandaries. Reproductive Biology and Endocrinology 1(1):84-87.
37. Christians EC, Zhou Q, Renard JP, Benjamin IJ. (2003) Heat shock proteins in mammalian development. Seminars in Cell & Developmental Biology 14:283-290.
38. Li Z, Rezaei Sabet M, Zhou Q, Liu X, Ding W, Zhang Y, Renard JP, Engelhardt JF. (2003) Developmental capacity of ferret embryos by nuclear transfer using G0/G1-phase fetal fibroblasts. Biol Reprod. 68(6):2297-2303.
39. Renard JP, Zhou Q, LeBourhis D, Heyman Y, Chavatte-Palmer P, Hue I and Vignon X. (2002) Recent advances in nuclear transfer technologies. Theriogenology 57 (1):203-222.
40. Heyman Y, Zhou Q, Lebourhis D, Chavatte-Palmer P, Renard JP, Vignon X. (2002) Novel approaches and hurdles to somatic cloning in cattle. Cloning Stem Cells 4(1):47-55.
41. Vignon X, Zhou Q, Renard JP. (2002) Chromatin as a regulative architecture of the early developmental functions of mammalian embryos after fertilization or nuclear transfer. Cloning and Stem Cells 4 (4):363-377.
42. Zhou Q, Jouneau A, Brochard V, Adenot P, Renard JP. (2001) Developmental potential of mouse embryos reconstructed from metaphase embryonic stem cell nuclei. Biol Reprod. 65(2):412-419.
43. Zhou Q, Boulanger L, Renard JP. (2000) A simplified method for the reconstruction of fully competent mouse zygotes from adult somatic donor nuclei. Cloning 2(1):35-44.

著作：

• 《2005高技术发展报告》，41-49，撰写其中《动物细胞核移植进展和展望》2005
• 《现代农业生物技术》，参编，中国农业出版社，2002年第二版
• 《生命科学》，参编，重庆出版社，1999年5月
• 《发育生物学》，黄秀英、劳为德、郑瑞珍、周琪等译，高等教育出版社，北京，1998
• 《神秘的克隆》，周琪、刘春巧、霍妍丽，中国教育科学出版社，北京，1997年8月.

专利：
Cozzi J, Qi Zhou, JP Renard " A procedure for rat cloning through nuclear transfer" ref: 03 06 223- PCT procedure pending （2003）