Qiang Wang, Jinhua Lu, Shuang Zhang, Shumin Wang, Weixiang Wang, Bingyan Wang, Fengchao Wang, Qi Chen, Enkui Duan, Michael Leitges, Andreas Kispert, and Haibin Wang*, 2013 Wnt6 is essential for stromal cell proliferation during decidualization in mice1. Biology of Reproduction 88(1):5, 1–9

Shuang Zhang, Shuangbo Kong, Jinhua Lu, Qiang Wang, Yongjie Chen, Weixiang Wang, Bingyan Wang, and Haibin Wang*, 2013 Deciphering the molecular basis of uterine receptivity. Molecular Reproduction & Development (Review article) 80:8–21

Jinhua Lu, Shuang Zhang, Haruo Nakano, David G. Simmons, Shumin Wang, Shuangbo Kong, Qiang Wang, Lianju Shen, Zhaowei Tu, Weixiang Wang, Bingyan Wang, Hongmei Wang, Yanling Wang, Johan H. Van Es, Hans Clevers, Gustavo Leone, James C. Cross*, Haibin Wang*, 2013 A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta. Plos Biology 11(4): e1001536

Miles El, O'gorman C, Zhao J, Samuel M, Walters E, Yi Yj, Sutovsky M, Prather Rs, Wells Kd, Sutovsky P, 2013 Transgenic pig carrying green fluorescent proteasomes. Proc natl acad sci usa. 110(16):6334-6339.

Aguilar ps#, Baylies mk#, Fleissner a#, Helming l#, Inoue n#, Podbilewicz b*, Wang h#, Wong m#(#, equal contribution.), 2013, Genetic basis of cell-cell fusion mechanisms. Trends in genetics. feb 27. [epub ahead of print]

Ji lei, Brkic′jelena, Liu ming, Fu guodong, Peng chun* ,Wang yan-ling*, 2013, Placental trophoblast cell differentiation: physiological Regulation and pathological relevance to preeclampsia (Review), Molecular Aspects of Medicine [epub ahead of print]

The first debate competition is preparing The state key laboratory of reproductive biology will hold the first session of debate competition. The title of the competition is “If sperm is more important than oocyte?” The leader of the district side is Wei Li and the anti-side is Xiaoyin Lv. All are welcome to join this competition!

The first ‘Voice Of Science’ forum of SKLRB graduate students The ‘Voice Of Science’ forum is the annual science communication party in SKLRB. This forum is to not only pick out the annual trump card from the graduate students, but also improve the scientific spark collision among all these young scientists. The four candidates are determined by all the PIs of SKLRB. Let’s wait and see who will be the final champion. • Time: 10 am to 12 am on 15^th September, 2012; • Place: B105, IOZ; • Judges: All the PIs of SKLRB.

 Dr.Chunsheng Han’s group in SKLRB collaborated with Dr. Fuquan Yang’s team in the Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, CAS in examining protein expression during mouse spermatogenesis using iTRAQ technology—an up-to-date high throughput quantitative proteomic strategy—coupled with in-depth bioinformatics analysis. Their integrative proteomic and transcriptomic analyses have revealed multiple post-transcriptional regulatory mechanisms of mouse spermatogenesis. This work provides a valuable inventory of proteins produced during mouse spermatogenesis and contribute to elucidating the mechanisms of gene regulation in mammalian spermatogenesis.These results were recently published in Molecular & Cellular Proteomics. More...

 Research group led by Prof. Dahua Chen created and characterized a mouse model carrying the human FMR1 premutation allele and show that FMR1 premutation RNA can cause a phenotype mimicking human “remature menopause” or “premature ovarian failure” (POF), the phenotype includes a reduction in the number of growing follicles in ovaries which is sufficient to impair female fertility, and alterations of selective serum hormone levels, including FSH, LH, and 17β-estradiol. The researchers also show that the FMR1 premutation allele can lead to reduced phosphorylation of Akt and mTOR proteins. These results were recently published in Human Molecular Genetics. More...

 Research group led by Prof. Yan-ling wang discovered that Plasma and placental productions of Activin A were significantly higher in preeclamptic patients when compared with normal pregnant subjects in a Chinese Han population. They found that abnormally high level of Activin A cause trophoblast cell apoptosis through activation of Nodal signaling. These results were recently published in The Journal Of Clinical Endocrinology & Metabolism. More...

 Research group led byProf. Yan-ling wang discovered that HGF could negatively self-control its regulatory effect on trophoblast cell invasion via enhancing proteolysis of its receptor. This study also showed that unbalanced HGF self-control by pathological conditions such as oxidative stress could lead to impeded placentation in relevance to preeclampsia. These results were recently published in The Journal Of Clinical Endocrinology & Metabolism. More...