Qi Zhou received a PhD in Physiology & Embryology from Northeast Agriculture University, China, 1996 (Thesis: Nuclear transfer and serial nuclear transfer research in rabbit). In 1997-1999 he held a postdoctoral and Associate Professor positition in the Institute of Developmental Biology, Chinese Academay of Sciences (CAS), and in 1999-2002 he was a postdoc and Project leader within the group of Prof. J.P. Renard (Developmental Biology and Reproduction, INRA, Jouy-en-Josas, France). In 2001 he was offered a 100 talent position in the Institute of Zoology, CAS, where he is currently Professor of Developmental Biology, Vice Director of State Key Lab of Reproductive Biology. His research focuses on the mechanisms of differentiation and de-differentiation, embryonic development of mammalian somatic cell nuclear transfer, cellular plasticity and totipotency of stem cells and somatic cells, with a goal of understanding the mechanisms of mammalian cloning and improving cloning efficiency.

　　Mechanism of embryonic development of mammalian somatic cell nuclear transfer, cellular plasticity and totipotency of somatic cells, animal cloning, therapeutic cloning and stem cells

(* correspondent author)

1. Zhou Q*, Renard JP, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J: Generation of Fertile Cloned Rats by Regulating Oocyte Activation. Science 2003, 302: 1179

2. Jifeng Yang*, Shihua Yang, Nathalie Beaujean, Yuyu Niu, Xiechao He, Yunhua Xie, Xianghui Tang, Liu Wang, Qi Zhou*, and Weizhi Ji*；Epigenetic Marks in Cloned Rhesus Monkey Embryos: Comparison with In Vitro Produced Counterparts. Bio Reprod/ 2006 / 051383 (in print)

3. Q.Zhou*, S.H.Yang, C.H.Ding, X.C.He, Y.H.Xie, .B.Hildebrandt, .M.Mitalipov, X.H.Tang, D.P.Wolf and W.Z.Ji. A comparative approach to somatic cell nuclear transfer in the rhesus monkey. Human Reproduction ,2006,21:2564–2571

4. Alice Jouneau, Qi Zhou, Anne Camus, Vincent Brochard, Linda Maulny, Jérome Collignon and Jean-Paul Renard. Developmental abnormalities of NT mouse embryos appear early after implantation. Development , 2006 133, 1597-1607

5. Tianqing Li, Shufen Wang, Yunhua Xie, Yongqing Lu, Xiuzhen Zhang, Liu Wang, Shihua Yang, Don Wolf, Qi Zhou* and Weizhi Ji*,Transplantable Neural Progenitor Populations Derived from Rhesus Monkey Embryonic Stem Cells. Stem Cells, 2005, 10:2026-2030

6. Tianqing Li, Shufen Wang, Yunhua Xie, Yongqing Lu, Xiuzhen Zhang, Liu Wang, Shihua Yang, Don Wolf, Qi Zhou* and Weizhi Ji*, Homologous Feeder Cells Support Undifferentiated Growth and Pluripotency in Monkey Embryonic Stem Cells. Stem cells, 2005, 10:2004-2008

7. Ziyi Li, Xingshen Sun, Juan Chen, Xiaoming Liu, Samantha M. Wisely, Qi Zhou, Jean-Paul Renard, John F. Engelhardt, Cloned ferrets produced by somatic cell nuclear transfer. Dev. Biol, 2006 No. of pages: 10; 4C: 4, 5

8. Xuemei Li, Ziyi Li , Alice Jouneau, Qi Zhou*, Jean-Paul Renard. Nuclear Transfer: New Advances and Quandaries. Reproductive Biology and Endocrinology, 2003, 1(1):84-87

9. Qi Zhou, Jouneau A, Brochard V, Adenot P, and Renard J.P. Developmental potential of mouse embryos reconstructed from metaphase ES nuclei. Biology of Reproduction, 65(2):284-296, 2001

10. Christians E.C., Zhou Q, Renard J.P., Benjamin I.J., Heat shock proteins in mammalian development. Seminars in Cell & Developmental Biology 14 (2003) 283–290

11. Renard J.P., Zhou Qi, LeBourhis D., Heyman Y., Chavatte-Palmer P., Hue I. and Vignon X. Recent advances in nuclear transfer technologies Theriogenology. 1;57 (1):203-222, 2002

12. Heyman Y, Zhou Q, Lebourhis P, Chavatte-Palmer, Renard JP, Vignon X. Nowel approaches and hurdles to somatic cloning in cattle. Cloning and stem cell. 4 (1): 47-55, 2002

13. Vignon X, Zhou Q, Renard JP. Chromatin as a regulative architecture of the early developmental functions of mammalian embryos after fertilization or nuclear transfer. Cloning and Stem Cells. 2002;4 (4):363-77

14. Li Z, Rezaei Sabet M, Zhou Q, Liu X, Ding W, Zhang Y, Renard JP, Engelhardt JF. Developmental capacity of ferret embryos by nuclear transfer using g0/g1-phase fetal fibroblasts. Biol Reprod. 2003, 68 (6):2297-303

15. Qi Zhou, L Boulanger and JP Renard. A simplified method for the reconstruction of fully competent mouse zygotes from adult somatic donor nuclei. Cloning 2 (1) 35-44, 2000

Patent:

Cozzi J, Qi Zhou, JP Renard " A procedure for rat cloning through nuclear transfer" ref: 03 06 223- PCT procedure pending (2003 )