Dr. DUAN's research interests focused on two directions:

1) Molecular mechanisms around events of mammalian embryo implantation;

2) Skin derived stem cells and related researches.

1. The National Basic Research Program of China, 2006-2010, (2006CB504006) (research funding plus administration fee). (Leading Scientist and PI)

2. The National Basic Research Program of China, 2007-2011, (2006CB944006) (PI)

3. Grants of CAS Knowledge Innovation Program, 2007-2010 (KSCX2-YW-R-080) (PI)

4. National Natural Science Foundation of China. 2007-2009, (30670785) (PI)

5. National Natural Science Foundation of China. 2010-2012. (30971671) (PI)

1. Jing Li, Kazuhiro Kawamura, Yuan Cheng, Shuang Liu, Cynthia Klein, Shu Liu, En-Kui Duan, Aaron J. W. Hsueh*. Activation of dormant ovarian follicles to generate mature eggs. Proc Natl Acad Sci U S A. 2010, 107(22):10280-4
2. Qiu ZF, Miao CL, Li J, Lei X, Liu S, Guo W, Cao Y, Duan EK*. Skeletal myogenic potential of mouse skin-derived precursors. Stem Cells Dev. 2010, 19(2):259-268
3. Kuang H, Chen Q, Zhang Y, Zhang L, Peng H, Ning L, Cao Y, Duan E*.The cytokine gene, CXCL14, restricts human trophoblast cell invasion by suppressing gelatinase activity. Endocrinology. 2009, 150: 5596–5605
4. Zhang L, Guo W, Chen Q, Fan X, Zhang Y, Duan E*. Adam12 Plays a Role during Uterine Decidualization in Mice. Cell and Tissue Research. 2009, 338: 413-421
5. Haibin Kuang, Qi Chen, Xiujun Fan1, Ying Zhang, Li Zhang, Hongying Peng, Yujing Cao, Enkui Duan*. CXCL14 inhibits trophoblast outgrowth via a paracrine/ autocrine manner during early pregnancy in mice. Journal of Cellular Physiology. 2009, 221: 448-457
6. Zhou J, Su P, Wang L, Chen J, Zimmermann M, Genbacev O, Afonja O, Horne MC, Tanaka T, Duan E, Fisher SJ, Liao J, Chen J, Wang F.* mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc Natl Acad Sci U S A. 2009, 106(19):7840-5
7. Ying Zhang, Sha Peng, Haibin Kuang, Qi Chen, Shuang Liu, Li Zhang and Enkui Duan* Expression and regulation of Dickkopf2 during periimplantation in mice, J Reprod Dev. 2009 ,55(1):17-22
8. Kuang HB, Miao CL, Guo WX, Peng S, Cao YJ, Duan EK*Dickkopf-1 enhances migration of HEK293 cell by beta-catenin/E-cadherin degradation., Front Biosci. 2009,14:2212-20.
9. W. Guo, C. Miao, S. Liu, Z. Qiu, J. Li, and E. Duan* Efficient differentiation of insulin-producing cells from skin-derived stem cells, Cell Prolif. 2009,42(1):49-62.
10. Chen Q, Zhang Y, Lu J, Wang Q, Wang S, Cao Y, Wang H*, Duan E* Embryo-uterine cross-talk during implantation: the role of Wnt signaling. Mol Hum Reprod. 2009,15(4):215-21
11. Chen Q, Peng H Y, Zhang Y, Lei L, Cao YJ, Duan EK*. Embryo implantation: A time for recalling and forwarding. Chinese. Sci Bull, 2009, 54: 4083-4093
12. Liwei Jia, Jiaxi Zhou, Sha Peng, Juxue Li, Yujing Cao, Enkui Duan*. Effects of Wnt3a on proliferetion and of human epidermal stem cells. Biochemical and Biophysical Research Communications, 2008, 386:483-488
13. Liwei Jia, Chenglin Miao, Yujing Cao, En kui Duan*. Effects of Wnt proteins on cell proliferation and apoptosis in HEK 293 cells. Cell Biology International, 2008,32 :807-813
14. Ping Zhao, Ananya De, Zeng Hu, Jing Li, Sabine M. Mulders, Maarten D. Sollewijn Gelpke, En-Kui Duan*, and Aaron J. W. Hsueh*. Gonadotropin Stimulation of Ovarian Fractalkine Expression and Fractalkine Augmentation of Progesterone Biosynthesis by Luteinizing Granulosa Cells. Endocrinology, 2008, 149(6):2782–2789
15. Jing Li, Ph.D., Wei-Min Liu, Ph.D., Yu-Jing Cao, M.S., Sha Peng, Ph.D., Ying Zhang, Ph.D., and En-Kui Duan, Ph.D*. Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice. Fertility and Stertility, 2008,90(4):1470-1479
16. Juxue Li, Chenglin Miao, Weixiang Guo, Liwei Jia, Jiaxi Zhou, Baohua Ma, Sha Peng, huang Liu, Yujing Cao. Enkui Duan*. Enrichment of putative human epidermal stem cells based on cell size and collagen type IV adhesiveness. Cell Research 2008, 18:360-371
17. Bao-Hua Ma, Yu-Jing Cao, Wei-Bo Zheng, Jin-Ren Lu, Hai-bin Kuang, Xiao-Hua Lei, Yin-Huan Lv, Tao Zhang, En-Kui Duan*. Real-Time Micrography of Mouse Preimplantation Embryos in an Orbit Module on SJ-8 Satellite. Microgravity Sci. Technol 2008, 20:127–136
18. Peng S, Li J, Miao C, Jia L, Hu Z, Zhao P, Li J, Zhang Y, Chen Q, Duan E*. Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation. Reproduction. 2008 ,135(3):367-75
19. Shuang Liu and Enkui Duan*. Advances in the study on induced pluripotent stem cells. Chinese Science Bulletin，2008,53 (5):709-717
20. Yu-jing Cao, Xun-jun Fan, Zheng Shen, Bao-hua Ma, En-kui Duan*. Nitric oxide affects preimplantation embryonic development in a rotating wall vessel bioreactor simulating microgravity. Cell Biology Internationl. 2007, 31 (1): 24-29
21. Liu WM, Cao YJ, Li J, Fan XJ, Zhao P, Duan EK*. The expression of CD9 in the peri-implantation mouse uterus is up-regulated in an ovarian steroid hormone-dependent manner. Fertility and Sterility.2007, 87(3):664-670
22. Sha Peng, Chenglin Miao, Jing Li, Xiujun Fan, Yujing Cao and Enkui Duan*. 2006 Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. Biochemical and Biophysical Research Communications. 2006, 350(3):641-647
23. Jiaxi Zhou, Liwei Jia, Weimin Liu, Chenglin Miao, Shuang Liu, Yujing Cao, and Enkui Duan*. Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis. Human Reproduction. 2006,21(7):1698-1704
24. Shumin Bu, Chenfu Cao, Yongjun Yang, Chenglin Miao, Zeng Hu, Yujing Cao, Qingxiang Amy Sang, and Enkui Duan* .Localization and temporal regulation of tissue inhibitor of metalloproteinases-4 in mouse ovary. Reproduction. 2006,131: 1099-1107
25. Weiming Liu, Yujing Cao, Yongjun Yang, Zheng Hu, and Enkui2010-6-22Duan*. Tetraspanin CD9 regulates invasion during mouse embryo implantation. Journal of Molecular Endocrinology. 2006,36:121–130
26. Yongjun Yang, Weimin Liu, Jiaxi Zhou, Yujing Cao, Jing Li, Sha Peng, Li Wang, Jianggang Yuan, and Enkui Duan*. Expression and hormonal regulation of calcyclin-binding protein (CacyBP) in the mouse uterus during early pregnancy.Life Science. 2006, 78(7):753-760
27. Yongjun Yang, Yujing Cao, Shumin Bo, Peng Sha, Weimin Liu, and Enkui Duan*. Leptin-directed embryo implantation: Leptin regulates adhesion and outgrowth of mouse blastocysts and receptivity of endometrial epithelial cells. Animal Reproduction Science. 2006, 92(1-2):155-167
28. Shumin Bu, Yongjun Yang, Chenglin Miao, Hongjiang Li, Robert G. Newcomer, Qingxiang Amy Sang ,and Enkui Duan*. Developmental and hormonal regulation of meltrin beta (ADAM19) expression in mouse testes during embryonic and postnatal life. Life Science.2006, 79(22):2112-2118
29. Jing Li, Jian Zhang, Yujing Cao, Jiaxi Zhou, Weimin Liu, Xiujun Fan, and Enkui Duan*. Inhibition of the Beta-Catenin Signaling Pathway in Blastocyst and Uterus During the Window of Implantation in Mice. Biology of Reproduction. 2005,72(3): 700-706
30. Yi Tan*, Dongmei Tan, Mingzhong He, Meili Gu, Zhibiao Wang, Guoqing Zeng, and Enkui Duan. A Model for Implantation: Co-Culture of Blastocysts and Uterine Endometrium in Mice. Biology of Reproduction. 2005,72 (3):556-561 (highlight paper)
31. Li Wang, Enkui Duan, Liying Sung, ByeongSeon Jeong, Xiangzhong Yang, and X Cindy Tian. Generation and characterization of pluripotent stem cells from cloned bovine embryos. Biology of Reproduction. 2005,73(1):149-155
32. Jiaxi Zhou, Shuyi Chen, Weimin Liu, Yujing Cao, and Enkui Duan*. Enrichment and identification of human 'fetal' epidermal stem cells.Human Reproduction. 2004,19(4):968-974 (Cover paper)
33. Jiaxi Zhou, Liwei Jia, Yongjun Yang, Sha Peng, Yujing Cao, and Enkui Duan*.Enrichment and characterization of mouse epidermal stem cells. Cell Biology International.2004,28(7):523-529
34. Jian Zhang, Yunge Zhao, Yujing Cao, Qingxiang Amy Sang, and Enkui Duan* .Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo. Molecular Human Reproduction. 2003,9(3):143-149. (Cover paper).
35. Liquan Cai, Jian Zhang, and Enkui Duan*. Dynamic distribution of epidermal growth factor during mouse embryo peri-implantation. Cytokine.2003,23(6): 170-178
36. Bojie Dai, Yujing Cao, Jiaxi Zhou, Sumin Li, Xichao Wang, Dayuan Chen, Enkui Duan*. Abnormal expression of matrix metalloproteinase-2 and -9 in interspecific pregnancy of rat embryos in mouse recipients. Theriogenology. 2003,60(7): 1279-1291
37. Bojie Dai, Yujing Cao, Weimin Liu, Sumin Li, Yongjun Yang, Dayuan Chen, and Enkui Duan*. Dual roles of progesterone in embryo implantation in the mouse. Endocrine. 2003,21(2):123-132
38. Jian Zhang, Yujing Cao, Fuyang Li, Jing Li, Libo Yao, and Enkui Duan* Effects of Fibronectin, VEGF and Angiostatin on the Expression of MMPs through different signaling pathway in the JEG-3 cells. American Journal of Reproductive Immunology.2003,50:273-285
39. Wang HM, Li QL, Lin HY, Yu XD, Qian D, Dai JJ, Duan EK, and Zhu C. Expression of vascular endothelial growth factor and its receptors in the rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. Molecular Reproduction Development. 2003,65(2):123-131
40. Jian Zhang, Yujing Cao, Yunge Zhao, Qingxiang Amy Sang, and En-Kui Duan*. Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinases 4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3. Molecular Human Reproduction. 2002,8(7): 659-666 (Cover page paper)
41. Aizhen Xiao, Yunge Zhao, Enkui Duan *. Expression and regulation of fatty-acid amide hydrolase gene in the rat uterus during the estrous cycle and peri-implantation period. Molecular Human Reproduction. 2002,8(7): 651-658.
42. Weiming Liu，Enkui Duan*, Yujing Cao, and Guo Zeng. Effects of anandamide on embryo implantation in the mouse. Life Sciences.2002,71(14):1623-1632
43. Zhiyun Jia, Enkui Duan, Zhigang Jiang*, and Zuwang Wang. Copulatory plugs in masked palm civets: Prevention of semen leakage, sperm storage, or chastity enhancement? Journal of Mammalogy. 2002, 83(4):1035-1038